Table 4. Quantitative Determination of Kidney Profile Markers in Lithium-Heparinized Whole Blood from NSG Mice Bearing Orthotopic Pancreatic Tumors after Single Intravenous Injection of Free GEM and mPEG-b-PCC-g-GEM-g-DC (Abbreviated as F-GEM and P-GEM) at GEM Equivalent Dose of 40 mg/kg.
| samples | |||
|---|---|---|---|
|
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| parametersa | control | F-GEM | P-GEM |
| BUN (mg/dL) | 25 ± 0.8 | 23 ± 3.5 | 21.7 ± 2.8 |
| GLU (mg/dL) | 233 ± 22 | 209 ± 48 | 224 ± 21 |
| CRE (mg/dL) | 0.2 ± 0.1 | 0.25 ± 0.1 | 0.2 ± 0.1 |
| Ca (mg/dL) | 10.1 ± 0.2 | 9.9 ± 0.7 | 9.6 ± 0.3 |
| PHOS (mg/dL) | 8.6 ± 0.3 | 8.3 ± 1.1 | 8.9 ± 0.8 |
| Na+ (mmol/L) | 144 ± 2.2 | 150 ± 3 | 150 ± 1.8 |
| Cl−(mmol/L) | 105 ± 5.2 | 109 ± 4.4 | 107 ± 2.4 |
| K+(mmol/L) | 7.4 ± 0.7 | 8.7 ± 0.4 | 6.9 ± 0.5 |
| tCO2(mmol/L) | 18.7 ± 2.5 | 20.3 ± 4 | 17.2 ± 2.5 |
a
F-GEM, free gemcitabine; P-GEM, mPEG-b-PCC-g-GEM-g-DC; BUN, blood urea nitrogen; GLU, blood glucose; CRE, creatinine; Ca, calcium; PHOS, phosphorus; ALB, albumin; Na+, sodium ion; Cl−,chloride ion; K+, potassium ion; tCO2, total carbondioxide. Data are presented as the mean ± SD (n = 4).