Table 5. Quantitative Determination of Liver Profile Markers in Lithium-Heparinized Whole Blood after Single Intravenous Injection of Free GEM and mPEG-b-PCC-g-GEM-g-DC (Abbreviated as F-GEM and P-GEM) at GEM Equivalent Dose of 40 mg/kg in NSG Mice Bearing Orthotopic Pancreatic Tumors.
| samples | |||
|---|---|---|---|
| parametersa | control | F-GEM | P-GEM |
| ALT (U/L) | 37 ± 4.2 | 34 ± 6.5 | 34 ± 5.2 |
| ALP (U/L) | 35.5 ± 7.1 | 37.3 ± 5.8 | 42.4 ± 6.2 |
| TBIL (mg/dL) | 0.2 ± 0.09 | 0.2 ± 0.06 | 0.2 ± 0.05 |
| BA (μmol/L) | <1 | <1 | <1 |
| GGT (U/L) | <5 | <5 | <5 |
| CHOL (mg/dL) | 87.7 ± 9 | 95 ± 23 | 85 ± 8.2 |
| ALB (g/dL) | 3.2 ± 0.2 | 2.9 ± 0.1 | 2.7 ± 0.3 |
a
F-GEM, free gemcitabine; P-GEM, mPEG-b-PCC-g-GEM-g-DC; control mice refers the mice bearing pancreatic orthotopic tumor without treatment; ALT, alanine aminotransferase; ALP, alkaline phosphatase; TBIL, total bilirubin; BA, bile acid; GGT, gamma glutamyl transferase; CHOL, cholesterol; BUN, blood urea nitrogen; ALB, albumin. Data are presented as the mean ± SD (n = 4).