Skip to main content
. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Ann Surg. 2017 Dec;266(6):952–961. doi: 10.1097/SLA.0000000000002286

Table 2.

Risk of Bias Assessment for a Randomized Controlled Trial (based on Cochrane Collaboration’s tool of assessing risk of bias19) of Beta-Blockers after TBI

Study, Year Random Sequence Generation Allocation concealment Blinding of Outcome Assessment Incomplete Outcome data Selective Reporting Baseline Imbalance
Cruickshank 1987 (47) Unclear risk Unclear risk Low risk High risk
(CK-MB was measured in only 60 patients, noradrenaline was measured in only 69 patients, daily ECG was obtained in 104 patients, continuous blood pressure monitoring was available in 3 out of 4 study centers, 3 patients had incomplete outcome data because they were discharged from ICU to floor)		 Low risk High risk
(more patients with severe traumatic brain injury in the intervention group than in the control group; 14 vs. 6, respectively)

ICU: intensive care unit; ECG: electrocardiogram.