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. Author manuscript; available in PMC: 2018 Jun 12.
Published in final edited form as: Cell Rep. 2018 May 29;23(9):2758–2769. doi: 10.1016/j.celrep.2018.04.102

Figure 3. Regulators of Mitosis Are Overexpressed in Aneuploid Breast Tumors.

Figure 3

The 100 most overexpressed genes in the high-FA-ranking tumors (BrFA100) were identified by comparing RNA expression data of the 100 high-FA and low-FA tumors.

(A) The overlap of the BrFA100 genes, the CIN70 list, and genes present in 3–6 previously published proliferation signatures (Multiple Proliferation Signatures).

(B) STRING diagrams (http://string-db.org) of the BrFA100 list show a highly noded grouping of mitotic regulators, mitotic cell-cycle genes, and DNA replication and repair proteins. The top 10 GO terms of the BrFA100 list shows a strong enrichment of cell-cycle genes, which is driven by a high M-phase gene enrichment (Table S4).

(C) Specifically, we plotted the relative fold enrichment of genes in the chromosome segregation GO term in the BrFA100, CIN70, and six different proliferation signatures.

See also Table S4.

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