Figure 2.

Loss of epsins in endothelial cells inhibits tumor growth by producing upregulated, but non-functional tumor angiogenesis. (A) LLC tumor is much smaller in EC-iDKO mice, accompanied by upregulated, but dilated vessels in tumors; (B) Vessel function assay: FITC-Dextran perfusion suggests that tumor vessels in EC-iDKO mice are hyper leaky. Scale bars = 50 μm for A and B. Figure 2 is adapted with permission from ref. 20. Copyright 2012 ASCI