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Design of the UPI peptide. (A) Alignment of human epsin UIM, mouse epsin UIM, and yeast Vps27 UIM with UPI chimeric peptide; (B) iRGD binds integrin and goes through proteolysis. The last 4 amino acids (GPDC) will be removed by circulating proteases.[23] UPI peptide contains an epsin UIM, a PM targeting sequence from the Lyn kinase H4 domain, and a tumor homing sequence (iRGD). Figure 3 is adapted with permission from ref. 19. Copyright 2015 ASCI
