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. Author manuscript; available in PMC: 2018 Jun 12.
Published in final edited form as: Vessel Plus. 2017 Mar 31;1:3–11. doi: 10.20517/2574-1209.2016.01

Figure 8.

Figure 8

UPI peptide treatment produces upregulated but leaky vessels in tumors. (A) CD31 immunofluorescent staining for LLC or U87 tumors, showing the upregulated vessels in UPI-treated tumors. Scale bar: 100 μm; (B) Control or UPI peptide-treated s.c. U87 tumor-bearing mice were perfused with FITC-dextran for 10 min, following which the mice were killed. Tumors were fixed and processed for CD31 staining. Note that vessels in UPI-treated tumors were hyper leaky. Scale bar: 100 μm. (C) Transmission electron microscopy analysis of semi-thin sections from control and UPI peptide-treated s.c. implanted U87 tumors. Dotted red lines indicate tumor vessels; blue arrows depict red blood cell leakage from tumor vessels; and red arrows indicate dying tumor cells. Scale bar: 50 μm. (D) VEGFR2 expression in control or UPI peptide-treated s.c. LLC and U87 tumors. Figure 8 is adapted with permission from ref. 19. Copyright 2015 ASCI