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. 2018 May 30;2(3):031904. doi: 10.1063/1.5026419

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© 2018 Author(s).

2473-2877/2018/2(3)/031904/13

All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FIG. 1. — Development and characterization of a 2D model for directed cancer cell migration using a chemoattractant gradient in microchannels. (a) Simplified microchip design. To facilitate the cell entry into 10 μm-wide microchannels, the left end of microchannels was tapered (35 μm width). (b) Top and side views of the microchip; reservoirs were generated using a 6 mm-biopsy punch. (c) Mathematical modeling of the non-linear chemoattractant gradient across the microchannels. Example time points ranging from 6 to 30 h are shown. (d) Gradient of AlexaFluor 405 dextran across the microchannel length, measured at different times 6–30 h. Colors correspond to acquisition times indicated in (c).