Table 1. Clinical manifestations in mice.

Mouse groupsa
	Normal group	Control APS group	Mock DNA vector-treated APS group	β2-GPI DNA vaccine-treated APS group
aPTT (seconds)	29.4 ± 2.7**	83.7 ± 14.8	77.4 ± 24.3 ns	67.4 ± 23.6 ns
Platelet count (×103 cells/mm3)	684 ± 219*	264 ± 144	244 ± 147ns	338 ± 176ns
% Fetal loss	10 ± 9***	41 ± 19	45 ± 16 ns	36 ± 18ns

The data are presented as the means ± standard deviation of triplicate assays from 6–8 mice/group.

^nsp>0.05,

*p<0.05,

**p< 0.01,

***p< 0.001 versus the control APS group.

^anormal group, β2-GPI non-immunized mice; control APS group, saline-treated APS mice; mock DNA vector-treated APS group, mock plasmid-treated APS mice; β2-GPI DNA vaccine-treated APS group, β2-GPI DNA vaccine-treated APS mice.

APS, antiphospholipid syndrome; aPTT, activated partial thromboplastin time.