Table 3. Parameter estimates from the pharmacokinetic-pharmacodynamic time-to-event model.

Parameter	Day 42 study outcome
	All data		African children <15 kg		African children 15–25 kg		Southeast Asian pregnant women
	Population estimate (BS estimate)	%RSE (95% CI)	Population estimate (BS estimate)	%RSE (95% CI)	Population estimate (BS estimate)	%RSE (95% CI)	Population estimate (BS estimate)	%RSE (95% CI)
Baseline hazard (day−1)	0.00600 (0.0103)	110 (0.00231–0.0406)	0.00120 0.00120	23.4 (0.000775–0.00199)	0.00168 0.00264	158 (0.000370–0.00893)	0.00324 0.00329	30.8 (0.00149–0.00535)
Hazard half-life (day)	12.8 (14.3)	67.4 (6.92–31.8)	—		—		—
IC50 (ng/ml)	92.6 (94.7)	56.0 (10.3–202)	194 (465)	457 (35.2–2,410)	9.79 (18.5)	162 (0.703–87.1)	1,580 (863)	38.4 (307–1,600)
Slope	1.87 (2.98)	181 (0.979–9.46)	—		—		—

The relative standard error (%RSE) was calculated as $100\times \frac{\mathrm{S}\mathrm{t}\mathrm{a}\mathrm{n}\mathrm{d}\mathrm{a}\mathrm{r}\mathrm{d}\mathrm{d}\mathrm{e}\mathrm{v}\mathrm{i}\mathrm{a}\mathrm{t}\mathrm{i}\mathrm{o}\mathrm{n}}{\mathrm{A}\mathrm{v}\mathrm{e}\mathrm{r}\mathrm{a}\mathrm{g}\mathrm{e}\mathrm{p}\mathrm{a}\mathrm{r}\mathrm{a}\mathrm{m}\mathrm{e}\mathrm{t}\mathrm{e}\mathrm{r}\mathrm{e}\mathrm{s}\mathrm{t}\mathrm{i}\mathrm{m}\mathrm{a}\mathrm{t}\mathrm{e}}$ from 1,000 iterations of a non-parametric bootstrap (BS) procedure.

IC₅₀, half maximal inhibitory concentration.