Fig 7. Effects of oxaliplatin treatment on cytokine and chemokine mRNA expression.
To determine whether oxaliplatin treatment induced changes in inflammatory mediators within the colon, RT2 Profiler PCR arrays were performed using pooled RNA samples from (vehicle, n = 5; oxaliplatin, n = 4) samples. Oxaliplatin treatment caused the down-regulation of the cytokines IL-1β, IL-12β mRNA expression when compared to the vehicle-treated group (A). Oxaliplatin treatment induced the up-regulation of the chemokine Ccl2, and the down-regulation of Ccl5 and Ccl22 chemokine mRNA expression when compared to the vehicle-treated cohort (B).