Table 4. Main effects and interaction models for the effects of depression and abuse on systemic biomarkers, by HIV status.

Linear regression models were used. Abuse defined as childhood sexual abuse and adult sexual abuse reported at baseline.

Outcome (Log10 pg/mL)	Change in Outcome, Depression vs None	Change in Outcome, Abuse vs None	Change in Outcome, HIV+ vs HIV	HIV Abuse Interaction	p value	HIV Depression Interaction	p value
TNF-α	0.74	0.94	1.26	-2.21	<0.01	-0.79	0.23
IL-6	-0.40	0.54	0.43	-0.18	0.57	0.45	0.15
IL-1α	0.07	0.95	0.82	-1.66	<0.01	0.02	0.97
IL-1β	-0.25	0.12	-0.21	0.13	0.73	0.15	0.68
TGF-β	0.18	-0.71	-0.58	0.88	0.01	0.14	0.68
MIP-3α	-0.02	0.68	0.73	-1.84	<0.01	-0.98	0.03
IL-8	-0.24	-0.12	0.03	0.19	0.63	-0.14	0.72
MCP-1	0.02	-0.76	-0.04	1.55	<0.01	0.31	0.49
IP-10	0.37	0.67	1.12	-0.88	<0.01	-0.41	0.16
SLPI	-0.15	0.27	0.06	-0.32	0.33	0.10	0.76
Elafin	0.02	-0.02	0.10	-0.10	0.62	-0.08	0.70
HBD-2	0.04	-0.04	0.11	-0.26	0.46	-0.09	0.80
HNP1-3	-0.20	0.23	-0.18	-0.21	0.53	-0.10	0.77
TSP-1	0.06	0.25	0.30	-0.30	0.10	-0.13	0.49
Serpin A1	-0.12	-0.01	0.16	-0.18	0.57	0.16	0.61
Serpin A5	0.13	0.04	0.27	0.49	0.15	-0.07	0.84
Serpin B1	0.14	0.53	0.02	-0.09	0.76	-0.10	0.72
Cystatin A	-0.04	-0.10	-0.35	-0.16	0.72	-0.38	0.40
Cystatin B	-0.09	-0.29	0.08	0.68	0.11	-0.29	0.49
GRO-α	0.17	0.54	0.36	0.21	0.62	-0.23	0.59
VEGF	-0.08	0.37	0.53	0.04	0.92	0.16	0.69
PDGF	-0.28	-1.49	-1.46	1.81	<0.01	0.18	0.62
EGF	-0.47	-0.39	-0.41	0.34	0.36	0.57	0.13
FGF	0.13	0.14	0.65	-0.21	0.37	-0.06	0.78
IGF	0.14	0.23	0.31	-0.31	0.32	-0.51	0.10
Cathepsin B	-0.10	-0.15	-0.22	-0.15	0.51	0.24	0.29