Table 3. Associations between BRM promoter indels and colon cancer risk.
| Sub-cohort | Variable | Genotypes | Cases N (%) |
Controls N (%) |
OR (95% CI) | * P value |
|---|---|---|---|---|---|---|
| Colon cases + Controls | † BRM-741 and BRM-1321 genotype combination | |||||
| Category A. | ||||||
| Double wild-type genotype | 41 (14.64) | 81 (19.85) | 1 (reference) | |||
| No homozygous variant genotype | 148 (52.86) | 196 (48.04) | 1.65 (1.05, 2.63) | 0.03 | ||
| One homozygous variant genotype | 64 (22.86) | 81 (19.85) | 1.77 (1.05, 3.01) | 0.03 | ||
| Double homozygous variant genotype | 25 (8.93) | 48 (11.76) | 1.14 (0.60, 2.15) | 0.69 | ||
| Unknown | 2 (0.71) | 2 (0.49) | ||||
| Category C. | ||||||
| Double wild-type genotype | 41 (14.64) | 81 (19.85) | 1 (reference) | |||
| Other genotype combinations | 237 (84.64) | 325 (79.66) | 1.60 (1.04, 2.50) | 0.03 | ||
| Unknown | 2 (0.71) | 2 (0.49) |
CI, confidence interval; N, number; OR, odds ratio. P values < 0.05 are bolded.
* Adjusted for age, sex, number of first degree relatives with colorectal cancer, smoking status and body mass index. Please note that final models include only the patients with the available covariate data. For further information on genotype combinations/categories, please refer to Methods/S1 Table.
† Homozygous variant genotype is Ins/Ins genotype.