Table 3. MIC characteristics of selected compounds against C. difficile1.
Compounds | Range (μg/mL) | Mode (μg/mL) | MIC 50 (μg/mL) | MIC 90 (μg/mL) |
---|---|---|---|---|
OG253 (F1I) | 0.06–0.5 | 0.25 | 0.25 | 0.5 |
OG703 (F1I R13D) | 0.5–2 | 1 | 1 | 2 |
OG705 (F1L R13D) | 0.5–2 | 1 | 1 | 2 |
OG706 (F1I R13N) | 0.125–1 | 0.5 | 0.5 | 1 |
OG711 (F1I R13A) | 0.25–1 | 0.25 | 0.5 | 1 |
OG712 (F1L R13N) | 0.125–0.5 | 0.25 | 0.25 | 0.5 |
OG713 (F1L R13A) | 0.25–0.5 | 0.5 | 0.5 | 0.5 |
OG716 (F1V R13N) | 0.25–0.5 | 0.5 | 0.25 | 0.5 |
OG718 (F1I R13N Y20F) | 0.25–1 | 0.5 | 0.5 | 1 |
Vancomycin | 0.5–4 | 0.5 | 0.5 | 4 |
1. n = 8