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. Author manuscript; available in PMC: 2018 Jun 12.
Published in final edited form as: Cancer Discov. 2017 Mar 20;7(4):359–368. doi: 10.1158/2159-8290.CD-16-1292

Table 3.

Selected RNA modifiers involved in cancer

Gene Activity Link to cancer (reference)
DNMT2 m5C RNA methyltransferase Diminished activity associated with candidate mutations (51)
NSUN2 m5C RNA methyltransferase Copy-number gain (52), oncogene targeting (53,54), depletion increase tumor-initiating cells (5)
TET1 DNA and RNA m5C demethylase Mutations and deletions in leukemia (58), tumor suppressor role (59)
WTAP Cofactor for m6A RNA methyltransferase Binding partner of the tumor suppressor WT1 (61), regulates cell cycle progression (62)
FTO m6A RNA demethylase Variants associated with melanoma risk (70), promotes leukemia (72) and breast cancer (73,74)
ALKBH5 m6A RNA demethylase Knock-out impact the p53 network (69), overexpression increases breast cancer stem cells (75)
ALKBH3 m1A RNA demethylase and DNA repair Protection against alkylation damage (76)
DKC1 Pseudouridine synthase Mutated in dyskeratosis congenita (30,79), regulates translation of tumor suppressor proteins (80)
Dis3L2 Exoribonuclease for the poly (U) tail Mutated in association with the development of Wilms’ tumors (85)