Table 4.
Adjusted ORs of the Final Imputed and Matched Models for 7-Day PPA at Three Time Points
| Covariate | 3 months | 6 months | 9 months | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 5% | 95 % |
P- value |
OR | 5% | 95 % |
P- value |
OR | 5% | 95 % |
P- value |
|
| Varenicline (3 mg) | 2.67 | 1.06 | 6.70 | 0.033 | 2.96 | 1.23 | 7.12 | 0.013 | 3.24 | 1.37 | 7.66 | 0.007 |
| Age (mean) | 1.00 | 0.95 | 1.06 | 0.955 | 1.03 | 0.97 | 1.09 | 0.286 | 1.03 | 0.98 | 1.07 | 0.279 |
| Sex (female) | 1.12 | 0.38 | 3.28 | 0.831 | 1.40 | 0.47 | 4.14 | 0.539 | 1.05 | 0.38 | 2.86 | 0.929 |
| FTND (mean score) | 0.83 | 0.60 | 1.15 | 0.255 | 0.94 | 0.65 | 1.36 | 0.748 | 0.96 | 0.65 | 1.42 | 0.841 |
| CPD (mean #) | 1.06 | 0.98 | 1.15 | 0.174 | 1.01 | 0.93 | 1.10 | 0.743 | 0.97 | 0.89 | 1.05 | 0.461 |
| CES-D (mean score) | 0.94 | 0.83 | 1.07 | 0.348 | 0.96 | 0.87 | 1.07 | 0.448 | 0.94 | 0.83 | 1.06 | 0.336 |
| Sleep (mean score) | 0.98 | 0.89 | 1.09 | 0.753 | 1.01 | 0.92 | 1.11 | 0.835 | 0.97 | 0.87 | 1.08 | 0.537 |
| PANAS (mean score) | ||||||||||||
| Positive | 0.95 | 0.87 | 1.03 | 0.183 | 0.99 | 0.92 | 1.07 | 0.842 | 0.96 | 0.89 | 1.04 | 0.357 |
| Negative | 1.00 | 0.91 | 1.10 | 0.945 | 0.95 | 0.87 | 1.05 | 0.308 | 0.98 | 0.90 | 1.07 | 0.675 |
| WSWS (mean score) | ||||||||||||
| Anxiety | 1.04 | 0.84 | 1.28 | 0.741 | 1.09 | 0.87 | 1.38 | 0.445 | 1.05 | 0.88 | 1.24 | 0.587 |
| Craving | 1.09 | 0.90 | 1.30 | 0.368 | 1.13 | 0.95 | 1.36 | 0.167 | 1.09 | 0.87 | 1.36 | 0.442 |
| PHQ (Diagnosis) | ||||||||||||
| Anxiety | 0.96 | 0.26 | 3.48 | 0.944 | 0.42 | 0.05 | 3.88 | 0.446 | 0.76 | 0.18 | 3.29 | 0.715 |
| Alcohol | 0.24 | 0.02 | 2.71 | 0.241 | 0.58 | 0.11 | 2.94 | 0.5 | 0.83 | 0.18 | 3.76 | 0.807 |
| Panic | 0.01 | 0.01 | 10.8 | 0.993 | 0.01 | 0.01 | 5.99 | 0.997 | 0.67 | 0.00 | 3.24 | 0.999 |
| Depression | 3.58 | 0.32 | 39.5 | 0.293 | 0.87 | 0.09 | 8.34 | 0.902 | 0.90 | 0.06 | 13.4 | 0.940 |
| MOTIVATION* | 0.97 | 0.47 | 1.99 | 0.932 | 1.23 | 0.60 | 2.54 | 0.571 | 1.04 | 0.54 | 1.97 | 0.911 |
| CPD (7-day PP)¥ | 0.82 | 0.69 | 0.97 | 0.023 | 0.89 | 0.76 | 1.03 | 0.122 | 1.00 | 0.91 | 1.10 | 0.974 |
Abbreviations: OR, odds ratio; 7-Day PPA, 7-day point prevalence abstinence; CPD, cigarettes/day; FTND, Fagerström Test for Nicotine Dependence; CES-D, Center for Epidemiologic Studies Depression Scale; PANAS, Positive and Negative Affect Schedule; WSWS, Wisconsin Smoking Withdrawal Scale; PHQ, Patient Health Questionnaire
*
Motivation was assessed on a Likert scale of one item: How motivated are you to quit smoking? Not Motivated=1, Somewhat Motivated=2, Neutral=3, Motivated=4, and Very Motivated=5.
¥
CPD (7-day PP), cigarettes per day as 7-day point prevalence, before patients chose to increase dose to 3 mg or to maintain the 2-mg dose