Table 1.

Platelet receptors with known roles in metastasis

Molecule	Effect on metastasis	References
GPIbα	Reduced experimental metastasis of melanoma cells in GPIbα−/− mice	(Jain et al., 2007)
GPVI	Reduced experimental metastasis of melanoma and Lewis lung carcinoma in GPVI−/− mice	(Jain et al., 2009)
P-Selectin	Reduced metastasis of B16 cells in P-sel−/− mice	(Becker et al., 2017; Qi et al., 2014)
NFE2	Fewer lung metastases after intravenous injection of melanoma cells	(Camerer et al., 2004)
Par4	Fewer lung metastases after intravenous injection of melanoma cells	(Camerer et al., 2004)
Gαq	Reduced experimental metastasis of B16-BL6 melanoma and Lewis lung carcinoma cells following intravenous injection	(Palumbo et al., 2005)
LPA	Reduced bone metastasis of breast cancer after LPA deprivation or LPAR overexpression in tumor cells	(Boucharaba et al., 2004; Leblanc et al., 2014)
β3 integrin	Reduced bone metastasis of B16 melanoma cells after intracardiac injection	(Bakewell et al., 2003)
α6β1 integrin	Reduced metastasis of AT-3, B16F10, MC38 and E0771 cancer cells in α6β1 integrin−/− mice	(Mammadova-Bach et al., 2016)
CLEC2	Reduced metastasis of CHO cells by inhibition of Podoplanin-CLEC-2 binding	(Takagi et al., 2013)
P2Y12	Reduced metastasis of Lewis lung carcinoma and B16 melanoma cells	(Wang et al., 2013)