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Platelet released factors important for tumor angiogenesis
| Effect on angiogenesis | Molecule | |
|---|---|---|
| Alpha granules | Pro-angiogenic | SERPINE1 |
| EGF | ||
| PDGF | ||
| bFGF | ||
| IGF | ||
| VEGF | ||
| TP (PD-ECGF) | ||
| IL-1β | ||
| SDF-1 | ||
| Anti-angiogenic | ANGTP1 | |
| S1P | ||
| PF4 | ||
| TSP1 | ||
| PGK | ||
| Endostatin | ||
| TIMPs (TIMP-1, -2, -4) | ||
| Pro- and anti-angiogenic | MMPs (MMP-1, -2, -3, -9, -14) | |
| TGFβ | ||
| HGF | ||
| Dense granules | Pro-angiogenic | Epinephrine |
| ATP, ADP | ||
| Anti-angiogenic | TFIP | |
| Pro- and anti-angiogenic | Histamine | |
| Serotonin |
