Skip to main content
. Author manuscript; available in PMC: 2019 Aug 15.
Published in final edited form as: Brain Res. 2018 Feb 17;1693(Pt A):75–91. doi: 10.1016/j.brainres.2018.02.018

Figure 3. Transmission of a neurodegenerative signal from axon to the cell body in AD.

Figure 3

Aggregates of oligomeric Aβ1-42 trigger, via a currently unknown signaling mechanism, an increased anterograde transport of specific mRNAs from the cell soma into axon terminals. One of these mRNA encodes the transcription factor ATF4 that is locally translated. A locally assembled signaling complex containing ATF4 is retrogradely transported to the cell soma, where it enters the nucleus and induces the expression of the transcription factor CHOP, causing cell death.