| Gap43 |
Axonal growth |
SMA |
Reduced in motor neuron axons upon SMN depletion |
(Fallini et al., 2016) |
| β-actin |
Cytoskeletal protein |
SMA |
Reduced in motor and sensory neuron axons upon SMN depletion, impaired local axonal translation upon SMN depletion |
(Jablonka et al., 2006; Rathod et al., 2012; Rossoll et al., 2003) |
| Nrn1 |
Neuron projection extension, synapse formation and stability |
SMA |
Reduced in soma and neurites of cortical neurons upon SMN depletion |
(Akten et al., 2011) |
| Anxa2a |
Ca2+-binding protein associated with plasma membrane and cytoskeleton |
SMA |
Reduced in NSC-34 neurites upon SMN depletion |
(Rage et al., 2013) |
| Cox4i2 |
Cytochrome C oxidase subunit |
SMA |
Reduced in NSC-34 neurites upon SMN depletion |
(Rage et al., 2013) |
| 195 mRNAs |
Axon growth and synaptic activity |
SMA |
Mostly down-regulation in axons of primary motor neurons upon SMN depletion |
(Saal et al., 2014) |
| Nef-L |
Neuronal cytoskeletal protein |
ALS-TDP |
Impaired transport of Nef-L-containing granules in motor neuron axons |
(Alami et al., 2014) |
| futsch/MAP1B |
Microtubule assembly |
ALS-TDP, ALS-C9orf72 |
Reduced transport and translation of futsch mRNA in motor neuron axons |
(Coyne et al., 2014) |
| Ddr2 |
Cell growth and migration |
ALS-TDP, ALS-FUS |
Mislocalization of Ddr2 mRNA |
(Yasuda et al., 2017) |
| kinesin-1 |
Cargo transport |
ALS-FUS |
Sequestered in FUS aggregates |
(Yasuda et al., 2017) |
| 565 mRNAs |
Diverse axonal functions and metabolic processes |
ALS-TDP, ALS-SOD1 |
Altered axonal levels of mRNAs and miRNAs |
(Rotem et al., 2017) |
| Atf4 |
Transcription factor |
AD |
Aβ1-42 exposure increases axonal localization and local translation followed by retrograde transport |
(Baleriola et al., 2014) |
