Figure 2. FMRP and TDP-43 cause different clinical syndromes during lifespan.
Diseases associated with FMRP: fragile X syndrome (FXS), Fragile X-associated primary ovarian insufficiency (FXPOI), Fragile X-associated tremor/ataxia syndrome (FXTAS). Diseases associated with TDP-43 proteinopathy: amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Known mRNA targets known to date, as shown.