Table 2.
Differentially expressed genes between each endotype (≥ 2-fold change and p < 0·05)
| Gene symbol | EoEe1 | Adjusted p-value | Gene symbol | EoEe2 | Adjusted p-value | Gene symbol | EoEe3 | Adjusted p-value | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| FC (EoEe1 vs. EoEe2) | FC (EoEe1 vs. EoEe3) | FC (EoEe2 vs. EoEe1) | FC (EoEe2 vs. EoEe3) | FC (EoEe3 vs. EoEe1) | FC (EoEe3 vs. EoEe2) | ||||||
| ALOX12 | 3·3 | 6·3 | 6·0E-06 | ACTG2 | 28·9 | 44·2 | 2·0E-07 | ACPP | −2·8 | −3·1 | 9·2E-09 |
| ALOX15 | −263·1 | −176·4 | 3·3E-11 | CCR3 | 24·0 | 12·9 | 8·7E-11 | CITED2 | −2·9 | −5·7 | 7·6E-08 |
| APOBEC3A | −11·0 | −8·3 | 6·8E-08 | CLEC16A | 3·3 | 3·0 | 1·5E-07 | CTNNAL1 | −5·9 | −8·0 | 2·9E-10 |
| CDA | 10·4 | 10·1 | 7·0E-09 | FFAR3 | 18·0 | 14·5 | 1·6E-06 | EML1 | −10·7 | −5·6 | 1·6E-06 |
| COL8A2 | −6·3 | −4·3 | 2·8E-04 | FKBP5 | 3·2 | 5·1 | 1·0E-05 | FLG | −6·4 | −5·5 | 1·3E-07 |
| CRISP3 | 307·6 | 540·6 | 6·0E-11 | HPGDS | 9·1 | 6·1 | 1·8E-07 | GRPEL2 | −3·4 | −4·0 | 2·7E-09 |
| ENDOU | 6·1 | 5·6 | 1·0E-08 | IL4 | 9·9 | 10·8 | 1·0E-08 | MT1M | −4·9 | −4·5 | 1·2E-05 |
| EPB41L3 | −3·3 | −2.0 | 1·5E-02 | IL5RA | 7·3 | 7·8 | 1·1E-06 | PNLIPRP3 | −21·8 | −12·8 | 2·4E-09 |
| GCNT3 | −3·6 | −2·7 | 8·0E-07 | KRT23 | 5·4 | 3·1 | 1·2E-05 | TSPAN12 | −10·1 | −5·3 | 2·0E-07 |
| HILPDA | 5·3 | 7·5 | 3·9E-09 | LRRC32 | 7·1 | 9·2 | 1·4E-07 | ||||
| IGFL1 | 2·9 | 2·7 | 1·4E-03 | MUC4 | 7·1 | 4·2 | 2·3E-08 | ||||
| PLAUR | −7·3 | −4·4 | 9·0E-07 | NTRK1 | 8·4 | 10·6 | 2·3E-08 | ||||
| SPINK7 | 4·9 | 5·3 | 1·9E-05 | PTGFRN | 2·5 | 2·4 | 1·2E-07 | ||||
| UPK1A | 5·4 | 9·1 | 4·3E-06 | RGS9BP | 14·8 | 21·1 | 3·4E-06 | ||||
| ZNF365 | 2·8 | 5·5 | 3·5E-06 | RUNX2 | 7·9 | 6·1 | 2·7E-08 | ||||
| SAMSN1 | 13·4 | 7·2 | 1·0E-08 | ||||||||
| TGFB1 | 2·5 | 2·2 | 2·3E-05 | ||||||||
| TSLP | 20·8 | 14·6 | 1·6E-06 | ||||||||
| UPK1B | 4·6 | 3·3 | 3·1E-04 | ||||||||
| WDR36 | 3·2 | 4·1 | 8·1E-09 | ||||||||
EoE=eosinophilic esophagitis. EoEe=eosinophilic esophagitis endotype. FC=fold change.