Table 5.

Estimated permeability of different membranes used in tissue barrier and co-culture models, calculated based on pore size, porosity, and membrane thickness. IP-DiLL(IP-dipin Laser Lithography photoresist), PC (Polycarbonate), Pnc-Si (Porous nanocrystalline Silicon), PDMS (Polydimethylsiloxane), SiN (Silicon nitride)

Material	Commercially available?	Permeability or Conductance Diffusive/Hydraulic/Electric	Tissue type	Goal of the study
IP-DiLL photoresist	No –two photon lithography	1.1 · 10−5 s/m3 4.5 · 10−6 pas · s/m3 2.2 · 105 S−1	bEnd.3 and U87 glioblastoma	On chip BBB127
PC	Yes – Track etched – AR- Brown	3.5 · 10−8 s/m3 3.2 · 10−9 pas · s/m3 270 S−1	CHO cells	Rapid shear-free delivery of soluble factors over large culture area20
PDMS	No – Custom casting	5.7 · 10−7 s/m3 pas 2.3 · 10−5 · s/m3 1.1 · 104 S−1	Caco-2 BEE	On chip TEER measurement correction104
pnc-Si and SiN	No – rapid phase transition and lithography	8.6 · 10−4 s/m3 8.6 · 10−8 pas · s/m3 1.0 · 107 S−1	neutrophils	Shear-free chemotaxis and cell labeling21