Table 2.
Ocular findings between sequences
| A sequence (PRO-122 → KOF) | B sequence (KOF → PRO-122) | |||||
|---|---|---|---|---|---|---|
| Baseline | Week 4 | Week 8 | Baseline | Week 4 | Week 8 | |
| TBUT, Mean ± SD | 6.46 ± 3.3 | 6.65 ± 2.9 | 6.08 ± 1.7 | 7.30 ± 1.8 | 6.41 ± 1.4 | 6.74 ± 2.4 |
| Conjunctival hyperemia, n (%) | 19 (39.6) | 18 (37.5) | 10 (20.8) | 6 (11.1)* | 14 (25.9) | 7 (13.0) |
| Tearing, n (%) | 9 (18.8) | 8 (16.7) | 7 (14.6) | 2 (3.7)+ | 9 (16.7) | 9 (16.7) |
| Chemosis, n (%) | 0 (0) | 0 (0) | 0 (0) | 2 (3.7) | 2 (3.7) | 0 (0) |
| Eye burning, n (%) | 16 (33.3) | 12 (25.0) | 14 (29.2) | 18 (33.3) | 18 (33.3) | 19 (35.2) |
| Foreign body sensation, n (%) | 14 (29.2) | 14 (29.2) | 5 (10.4) | 14 (25.9) | 16 (29.6) | 7 (13.0) |
Comparisons between sequences, Fisher’s exact test for hyperemia at baseline, *p = 0.001, and tearing, +p=0.023. A: n = 48; B: n = 54
TBUT tear break-up time (s)