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. 2018 Jun 12;8:8983. doi: 10.1038/s41598-018-27318-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional annotation of DEGs in accordance with euKaryotic Orthologous Groups (KOG) categories. All development stage-associated DEGs were assigned to the 26 KOG functional categories using BLASTx. Bars indicate the number of genes in each KOG category that revealed significant changes in expression (log₂ ratio ≥ 2) between the two developmental stages in L. edodes. The black and gray bars represent the up- and down-regulated DEGs of the mature fruiting body in L. edodes, respectively.