Table 4.
Analyses of the effects of the degree of ischemia-reperfusion injury on the risk of hepatocellular carcinoma recurrence after liver transplantation adjusted for the confounding influence of independent risk factors.
| Factor | HR | 95% CI | p | Adjusted for the effects of: |
|---|---|---|---|---|
| Post-reperfusion AST activity (continuous) | 1.10 | 0.70–1.74 | 0.683 | Tumor number |
| Post-reperfusion AST activity (categorical) | 1.20 | 0.51–2.85 | 0.677 | Tumor number |
| Post-reperfusion AST activity (continuous) | 1.11 | 0.70–1.74 | 0.667 | Alpha-fetoprotein concentration |
| Post-reperfusion AST activity (categorical) | 1.10 | 0.46–2.62 | 0.825 | Alpha-fetoprotein concentration |
| Post-reperfusion AST activity (continuous) | 1.31 | 0.76–2.25 | 0.332 | Microvascular invasion |
| Post-reperfusion AST activity (categorical) | 1.67 | 0.70–3.99 | 0.250 | Microvascular invasion |
| Post-reperfusion AST activity (continuous) | 1.25 | 0.75–2.09 | 0.398 | Poor tumor differentiation |
| Post-reperfusion AST activity (categorical) | 1.43 | 0.60–3.41 | 0.425 | Poor tumor differentiation |
| Post-reperfusion ALT activity (continuous) | 1.02 | 0.64–1.62 | 0.931 | Tumor number |
| Post-reperfusion ALT activity (categorical) | 0.71 | 0.27–1.87 | 0.483 | Tumor number |
| Post-reperfusion ALT activity (continuous) | 0.96 | 0.61–1.51 | 0.856 | Alpha-fetoprotein concentration |
| Post-reperfusion ALT activity (categorical) | 0.66 | 0.25–1.75 | 0.403 | Alpha-fetoprotein concentration |
| Post-reperfusion ALT activity (continuous) | 1.14 | 0.70–1.87 | 0.595 | Microvascular invasion |
| Post-reperfusion ALT activity (categorical) | 0.90 | 0.34–2.37 | 0.827 | Microvascular invasion |
| Post-reperfusion ALT activity (continuous) | 1.08 | 0.65–1.79 | 0.766 | Poor tumor differentiation |
| Post-reperfusion ALT activity (categorical) | 0.89 | 0.33–2.39 | 0.824 | Poor tumor differentiation |
| Post-reperfusion LDH activity (continuous) | 1.18 | 0.78–1.81 | 0.435 | Tumor number |
| Post-reperfusion LDH activity (categorical) | 1.69 | 0.74–3.85 | 0.211 | Tumor number |
| Post-reperfusion LDH activity (continuous) | 1.06 | 0.69–1.63 | 0.782 | Alpha-fetoprotein concentration |
| Post-reperfusion LDH activity (categorical) | 1.77 | 0.77–4.06 | 0.176 | Alpha-fetoprotein concentration |
| Post-reperfusion LDH activity (continuous) | 1.06 | 0.69–1.65 | 0.784 | Microvascular invasion |
| Post-reperfusion LDH activity (categorical) | 1.31 | 0.57–3.03 | 0.521 | Microvascular invasion |
| Post-reperfusion LDH activity (continuous) | 1.09 | 0.70–1.69 | 0.709 | Poor tumor differentiation |
| Post-reperfusion LDH activity (categorical) | 1.41 | 0.61–3.27 | 0.427 | Poor tumor differentiation |
HR – hazard ratio; 95% CI – 95% confidence interval; AST – aspartate transaminase; ALT – alanine transaminase; LDH – lactate dehydrogenase.