Table 2.

Best Model Results for BPI Worst Pain and FACT-P Trial Outcome Index

	Results for Best Model: Row 1 = Model coefficient values Row 2 = p-value
Domain	Intercept	Treatment	Time	Baseline Score	Time-squared
BPI Worst Pain	0.52 (< 0.0001)	−0.10 (0.39)	0.002 (0.78)	0.42 (< 0.0001)	0.0006 (0.001)
FACT-P Trial Outcome Index	32.86 (< 0.0001)	1.78 (0.02)	−0.21 (< 0.0001)	0.60 (< 0.0001)	N/A

Table shows the best model results for the BPI worst pain scores and FACT-P trial outcome index. We used linear mixed models with random effects for the slope and intercept, with a specified compound symmetric correlation structure to account for autocorrelation of serial measures within patients. For each outcome, we examined whether scores differed over time by arm using a treatment by time interaction (both linear and quadratic); if no interaction as present, we modeled time as both linear and quadratic. Best model fit was determined as shown in Additional file 1: Table S1