Figure 8.

Dendrimeric FnIII1-AB induce neurite outgrowth through FGFR and MEK1/2. CGNs were treated for 24 h with different concentrations of the FGFR kinase inhibitor SU5402 (a) or the MEK inhibitor U0126 (b) in the absence (black curves) or presence (blue curves) of 3.9 μM dendrimeric FnIII1ab. Average neurite lengths were estimated by a stereological approach from recorded micrographs. Data were normalized to the negative control (0 μM inhibitor in the absence of peptide) and are shown as mean and SEM (n = 2). The effect of the total average neurite length per cell for FnIII1-AB cultured with inhibitor can be found in Supplementary Table S3.