Table 1.

Association between MTHFD2 network gene loci and plasma metabolites directly or indirectly associated with glycine metabolism

Gene	Metabolite	SNP	p value
MTHFD2	N-acetylglycine	rs10174907	1.43E-05
EPAS1	N-acetylglycine	rs1530628, rs2197698, rs1530627	8.69E-05, 9.45E-05, 9.76E-05
GLDC	Glycine	rs2297442	2.94E-05
AARS	Tyrosine	rs9936903	1.89E-08
LTA4H	Methionine	rs12579455	4.99E-05
SETX	Citrulline	rs612169, rs545971, rs674302, rs514659	5.91E-05, 6.35E-05, 6.39E-05, 6.86E-05
EPAS1	Tryptophane	rs1530628	8.13E-05
PCK2	Glycerol 3-phosphate	rs1062230	2.60E-05