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. 2018 Jun 12;8:8938. doi: 10.1038/s41598-018-27211-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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UNC-16 and UNC-76 change mitochondrial flux in anterior TRNs. Mitochondrial anterograde and retrograde flux in the distal ALM processes in L3 animals of (A) wild type (jsIs609), unc-116(e2310), klc-2(km11), dhc-1(js319), unc-16(tb109), unc-16(e109), unc-76(n2397), unc-76(rh116) and double mutants [unc-16(e109) unc-116(e2310)], [unc-16(e109); klc-2(km11)] and [unc-116(e2310); unc-76(rh116)]. Data represented as Mean ± SEM. A: Anterograde; R: Retrograde. n ≥ 34 worms. Statistical tests used: The above multiple comparisons were done using multiple t-test with Sidak-Bonferroni correction. Black * are comparisons to respective wild type direction of movement. Red * are comparisons to respective directions of movement between motor; adaptor double mutants and corresponding motor subunit single mutants. Blue * are comparisons to respective directions of movement between motor; adaptor double mutants and corresponding adaptor single mutants. Green * are comparisons between anterograde and retrograde movements in the same genotype. p value * < 0.05, ** < 0.01, *** < 0.001. Comparisons that are not marked eg retrograde transport in tb109 to retrograde transport in wild type, are not statistically significant. (B) Representative kymographs of L3 wild type, unc-116(e2310), klc-2(km11), dhc-1(js319), unc-16(tb109) and unc-76(n2397) animals. Scale bars: x axis 10 μm, y axis 15 seconds.