Figure 4.
Facilitation of glutamate release mediated by presynaptic KAR activation requires Ca2+-calmodulin at PF-PuC synapses. (A) Time-course of KA (3 μM) effect on eEPSCs amplitude in control condition (circles) and in the slices treated with 25 μM W-7 (squares). Inset show traces before and after 4 min KA perfusion from W-7 treated slices. (B) Quantification of modulation observed in (A) and in the presence of 1 μM CMZ. The number of slices (from two to three mice) is indicated in parenthesis at the top of each bar. Results are expressed as means ± SEM (**P < 0.01, ANOVA test).