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. 2018 Jun 6;9:1272. doi: 10.3389/fimmu.2018.01272

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Copyright © 2018 Velu, Mylvaganam, Ibegbu and Amara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A model showing the predicted role of follicular homing CXCR5⁺ CD8 T cells in controlled SIV infection. In controlled SIV infection, the population of virus-specific CD8⁺ T cells expressing CXCR5 increases in lymphoid follicles. These CXCR5⁺ CD8 T cells can give rise to both CXCR5⁺ and CXCR5⁻ CD8 T cells that may be important for the maintenance of anti-viral CD8 T cells in both follicular and extrafollicular compartments. Thus, generating anti-viral CXCR5⁺ CD8 T cells by vaccination and therapeutic interventions may be critical for the control of chronic HIV/SIV infection.