Table 4.
Minimum inhibitory concentration of 2-aminoimidazole molecules on commensal microbiota library.
| Commensal strain | MIC (μg/mL) |
|||
|---|---|---|---|---|
| Compound 1 | Compound 2 | Compound 3 | Vancomycin | |
| B. fragilis | 10 | >10 | >10 | 2.5 |
| B. thetaiotaomicron | 5 | 10 | >10 | 1.25 |
| L. acidophilus | >10 | >10 | >10 | 0.31 |
| L. gasseri | >10 | >10 | >10 | 0.16 |
| C. scindens | 5–10 | 10 | >10 | 0.31 |
| C. hylemonae | 10 | 10 | >10 | 1.25–0.31 |
| E. coli | >10 | >10 | >10 | >10 |
| B. longum subsp. infantis | >10 | >10 | >10 | 0.63 |
Minimum inhibitory concentration (MIC) was determined by broth microdilution as per modified CLSI guidelines for anaerobes. Data represent mean values from triplicate trials.