Table 1. Replication results on three SNPs in ADD3 in Southern Han Chinese population using 510 cases and 1473 controls.

SNP	CHR	Gene	Left_gene	Right_gene	Cheng et al. (Hepatology, 2013) [8]	BP	A1/A2	Cases	Controls	OR (CI 0.95)	P	P_adj
				P_hwe=0.55
rs17095355	10	NA	XPNPEP1	ADD3	MAF case/control): 0.54/0.39	109975992	T/C	461/483	1212/1680	1.33 (1.15 ∼1.54)	1.60E-04	1.20E-04
					OR: 1.83 (1.45–2.31)		ADD	-	-	1.34 (1.15∼1.56)	1.50E-04	2.58E-04
					RISK allele: T		DOM	358/114	964/482	1.58 (1.24∼2.00)	1.70E-04	2.27E-04
					P-value: 5.32E-06		REC	103/369	248/1198	1.35 (1.04∼1.75)	0.02	0.03
				P_hwe=0.53
rs10509906	10	NA	XPNPEP1	ADD3	MAF (case/control): 0.14/0.23	109997916	C/G	200/786	610/2294	0.95 (0.79 ∼1.14)	0.58	0.53
					OR: 0.52 (0.38–0.71)		ADD	-	-	0.96 (0.80∼1.15)	0.64	0.75
					RISK allele: G		DOM	183/310	542/910	0.99 (0.80∼1.22)	0.92	1
					P value: 4.91E-05		REC	17/476	68/1384	0.75 (0.43∼1.28)	0.29	0.26
				P_hwe=0.87
rs2501577	10	ADD3	XPNPEP1	MXI1	*MAF (case/control): 0.54/0.42	110086929	G/A	461/479	1237/1671	1.31 (1.13 ∼1.51)	3.60E-04	4.03E-04
					OR: 1.61 (1.28–2.03)		ADD	-	-	1.30 (1.12∼1.51)	5.30E-04	4.29E-04
					RISK allele: G		DOM	357/113	972/482	1.57 (1.24∼2.00)	2.10E-04	2.17E-04
					P-value: 8.28E-05		REC	104/366	265/1189	1.26 (0.98∼1.63)	0.07	0.06

A1/A2 indicate the risk allele and protective allele to disease. F_A/F_U indicates risk allele frequency of the SNP in cases or controls. The P-value indicates the significance based on allelic association tests. The calculation of OR is also based on the risk allele of each SNP. Abbreviations: BP, base pair where the SNP is located; CHR, chromosome; Gene.refgene, the gene where the SNP is located at; OR, odds ratio.

^*Shows the association of rs2501575 which is in full LD (r² = 1) with rs2501577 in Chinese.