Table 3. The association of haplotypes derived from three SNPs on ADD3.
| SNP combination | Haplotype | F_A | F_U | DF | P | OR (CI 0.95) |
|---|---|---|---|---|---|---|
| rs17095355|rs10509906 | OMNIBUS | NA | NA | 2 | 4.23E-04 | - |
| Risk | TG | 0.48 | 0.41 | 1 | 2.23E-04 | 1.32 (1.15–1.53) |
| Protective | CG | 0.32 | 0.38 | 1 | 5.07E-04 | 0.76 (0.65–0.88) |
| rs10509906|rs2501577 | OMNIBUS | NA | NA | 2 | 3.97E-04 | - |
| Risk | GG | 0.49 | 0.43 | 1 | 2.25E-04 | 1.32 (1.15–1.53) |
| Protective | GA | 0.30 | 0.36 | 1 | 4.80E-04 | 0.75 (0.65–0.88) |
| rs17095355|rs2501577 | OMNIBUS | NA | NA | 3 | 2.67E-04 | - |
| Risk | TG | 0.46 | 0.39 | 1 | 4.82E-05 | 1.37 (1.18–1.58) |
| Protective | CG | 0.02 | 0.04 | 1 | 0.028 | 0.59 (0.38–0.93) |
| Protective | CA | 0.49 | 0.54 | 1 | 3.25E-03 | 0.80 (0.69–0.92) |
| rs17095355|rs10509906|rs2501577 | OMNIBUS | NA | NA | 4 | 2.19E-04 | - |
| Risk | TGG | 0.47 | 0.39 | 1 | 1.88E-05 | 1.38 (1.19–1.59) |
| Protective | CGG | 0.02 | 0.04 | 1 | 0.047 | 0.64 (0.41–0.99) |
| Protective | CGA | 0.29 | 0.34 | 1 | 1.79E-03 | 0.78 (0.66–0.91) |
F_A indicates risk allele frequency of the SNP in each subclinical group. F_U indicates protective allele frequency of the SNP in each subclinical group. Abbreviation: DF, degree of freedom.