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. 2018 Jun 6;9:540. doi: 10.3389/fphar.2018.00540

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Copyright © 2018 Cai, Hou, Zhao, Liu, He, Liu, Hua, Li, Huang, Ou, Luo and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Puerarin protected against abdominal aortic banding (AB)-induced cardiac fibrosis. (A) Gross hearts. (B) HE staining. (C) Heart weight/body weight (HW/BW) ratio and heart weight/tibial length (HW/TL) ratio. (D) Representative echocardiographic images. (E) Left ventricular function. (F) Indexes of cardiac structure. (G) Masson trichrome staining and immunohistochemical staining of collagen I and III. (H) Collagen volume fraction (CVF) of Masson trichrome staining. (I) Quantitative analysis of collagen I and collagen III in vivo. Sham, sham-operated group; AB, aortic banding group; Pue, puerarin-treated aortic banding group. ^∗P < 0.05 vs. Sham, ^∗∗P < 0.01 vs. Sham, ^#P < 0.05 vs. AB, ^##P < 0.01 vs. AB. n = 6 for each group.