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. 2018 Jun 6;9:540. doi: 10.3389/fphar.2018.00540

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Copyright © 2018 Cai, Hou, Zhao, Liu, He, Liu, Hua, Li, Huang, Ou, Luo and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Puerarin promoted the expression of Nrf2 in cultured neonatal rat cardiac fibroblasts. (A) Representative western blots and quantitative analysis of Nrf2 in nucleus and cytoplasm. (B) Representative fluorescence images showed the expression of Nrf2 in nucleus. AngII, 1 μM; puerarin, 100 μM; tBHQ, 50 nM; Brusatol, 100 nM. ^∗P < 0.05 vs. control, ^##P < 0.01 vs. AngII, ▵ ▵ P < 0.01 vs. puerarin + AngII. n = 6 for each group.