Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 6;9:540. doi: 10.3389/fphar.2018.00540

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Cai, Hou, Zhao, Liu, He, Liu, Hua, Li, Huang, Ou, Luo and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

p38-MAPK signal participated in regulating puerarin on cardiac fibrosis in vitro. (A) Representative western blots and Quantitative analysis of p38-MAPK, Nrf2, UGT1A1, collagen I, and collagen III in puerarin protecting against AngII-induced cardiac fibrosis. (B) Effects of SB203580 (inhibitor of p38-MAPK) on proliferation of NRCF by CCK-8 assay. (C,D) SB203580 inhibited AngII-induced cardiac fibrosis in intracellular ROS (by fluorometer and fluorescence microscopy). AngII, 1 μM; puerarin, 100 μM; SB203580, 10 μM. ^∗P < 0.05 vs. control (0 h), ^∗∗P < 0.01 vs. control (0 hr), ^#P < 0.05 vs. AngII, ^##P < 0.01 vs. AngII, △P < 0.05 vs. Pue + AngII. n = 6 for each group.