Table 1.
Parameters of the axon model, the microtubule model, and the crosslink model.
| Value | Unit | References | |
|---|---|---|---|
| AXON | |||
| Axon length | 40 | μm | Caminiti et al., 2013 |
| Axon diameter | 540 | nm | Hirokawa, 1982 |
| Microtubules per cross section | 9.5 | – | Bray and Bunge, 1981 |
| Cytosol viscosity | 5 | mPa·s | Haak et al., 1976 |
| MIRCOTUBULES | |||
| Microtubule length Microtubule stiffness | 1,200 | MPa | Gittes et al., 1993 |
| Microtubule area | 400 | nm2 | Suresh, 2007 |
| CROSSLINKS | |||
| Crosslink distance Crosslink angle | 45 | deg | Hirokawa, 1982 |
| Crosslink stiffness | 10 | MPa | Mallik et al., 2004 |
| Crosslink area | 1 | nm2 | de Rooij et al., 2016 |
| Crosslink attachment rate, k0 | 4 | 1/s | Wegmann et al., 2011; Igaev et al., 2014 |
| Crosslink bond strength, F0 | 1–100 | pN | [varied] |
The crosslink bond strength, F0, is the only unknown in our model. Here, we vary the bond strength over two orders of magnitude to explore its effects on axonal damage. All other parameters are known from the literature.