Figure 1.

Algorithm for diagnosis and therapy of thrombotic microangiopathy (modified according to Brocklebank et al. [7])

ADAMTS13: a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13; aHUS: atypical hemolytic uremic syndrome; G/L: Giga per liter; DIC: disseminated intravascular coagulopathy; GI: gastrointestinal; HELLP: hemolysis, elevated liver enzyme levels, and low platelet levels; HUS: hemolytic uremic syndrome; LDH: lactate dehydrogenase; CNS: central nervous system; SP-HUS: Streptococcus pneumoniae; STEC: Shiga toxin–producing Escherichia coli; Susp.: suspicion of; TMA: thrombotic microangiopathy; TTP: thrombotic-thrombocytopenic purpura