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. 2018 Jun 6;9:296. doi: 10.3389/fendo.2018.00296

Figure 4.

Figure 4

Follow-up of dexamethasone (DXM)-induced atrophy and recovery. (A) Representatives MRI slices showing thymus [region-of-interest (ROI), yellow] of wild-type (WT) and KO at d0 and d14 after DXM injection. Lines show three successive slices around the maximal ROI. (B) Evolution of thymic volumes normalized in% of d0 value is shown for WT (blue) and KO (red) mice treated with DXM (filled line, n = 6 per group) or control solution (dotted line, n = 4 per group). Paired t-test was used for effect of DXM vs d0. ap: < 0.05, bp < 0.01. Two-way ANOVA test (time and treatment) with Bonferroni post-test (WT vs KO for DXM or Ctrl treatment) was used for statistical analyze of genotype variation. *p < 0.05, ***p < 0.001. (C) Thymus weight, sjTREC and sj/dβ ratio of WT (blue) and KO (red) mice at d15 post DXM- (circle, n = 6 per group) or control-injection (square, n = 4 per group). Unpaired t-test was used for statistical analysis. *p < 0.05. (B,C) Data (mean ± SEM) are representative of two independent experiments.