Fig. 4.

Angptl4^−/− mice have improved glucose homeostasis. a Serum triglycerides, (b) total cholesterol, and (c) blood glucose levels in Angptl4^−/− and littermate control mice on a high-fat diet for 9 weeks. d Oral glucose tolerance test and (e) insulin tolerance test in the animals described in (a–c). All groups had 9–11 animals. Values are mean ± SEM. Statistical analysis by Welch’s t-test (a) and 2-way ANOVA with Sidak’s post-test (d, e), **p < 0.001, ****p < 0.0001. The study was conducted in three different cohorts of mice, with qualitatively similar results in each replicate