Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 13;8:9006. doi: 10.1038/s41598-018-27416-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Sort1 deficiency likely decreases body weight and plasma total cholesterol (TC) in female Ldlr^−/− mice via a KLF4-LXR signaling axis leading to decreased NPC1L1, and increased FGF21 and Adiponectin that together regulates white adipocyte formation, energy expenditure in BAT, and intestinal cholesterol absorption. Arrows indicate directionality. Dashed arrows indicate a plausible connection between KLF4 and LXR in select tissues, and that reduced NPC1L1 may partially regulate body weight via oxysterol mediated LXR-signaling.