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. 2018 Jun 13;8:9074. doi: 10.1038/s41598-018-27447-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A–C) Female cat, 5 years, with sporotrichosis and negative serology for FIV and FeLV. (A) Multiple ulcers on the flank and thigh in the first appointment before treatment with itraconazole. One of the lesions of the flank (arrow) was submitted to the first biopsy. (B) Time of the second biopsy of the same lesion (arrow) after 7 weeks of treatment. Remarkable regression of size and partial healing of the ulcer on the right flank submitted to the first biopsy, as well as of the other initial lesions. (C) Clinical cure after 16 weeks of treatment with itraconazole. (D–F) Female cat, 3 years, with sporotrichosis and negative serology for FIV and FeLV. (D) Ulcer on the tail before treatment with itraconazole submitted to the first biopsy. (E) Time of the second biopsy of the same lesion after 9 weeks of treatment. Note the stagnation of the ulcer on the tail. (F) Therapeutic failure after 36 weeks of itraconazole treatment. Persistence of the ulcer on the tail.