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. 2018 Jun 13;8:9074. doi: 10.1038/s41598-018-27447-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological changes in the skin lesion of a cat with sporotrichosis (the same as in Fig. 1A–C) whose outcome was clinical cure after 16 weeks of treatment with itraconazole. (A,B) Skin lesion sample at the time of the first biopsy before treatment. (A) Marked and diffuse pyogranulomatous dermatitis exhibiting multiple well-formed granulomas. H&E. (B) Note the black-stained single, round, budding yeast cell, demonstrating low fungal load. GMS. (C,D) Sample of the same skin lesion at the time of the second biopsy after 7 weeks of treatment. (C) Dermal fibrosis. H&E. (D) Absence of yeasts. GMS.