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. 2018 Jun 13;8:9074. doi: 10.1038/s41598-018-27447-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological changes in the skin lesion of a cat with sporotrichosis and seropositive for FIV whose outcome was therapeutic failure after 36 weeks of itraconazole treatment. (A,B) Skin lesion sample at the time of the first biopsy before treatment. (A) Fungus-rich granuloma containing abundant yeasts inside macrophages and few neutrophils, lymphocytes and plasma cells. H&E. (B) Abundant black-stained round yeasts, some with narrow-base single buds, or cigar-shaped cells. GMS. (C,D) Sample of the same skin lesion at the time of the second biopsy after 7 weeks of treatment. (C) Pyogranulomatous dermatitis exhibiting a poorly formed granuloma characterised by marked and diffuse infiltration of macrophages, neutrophils, plasma cells, and lymphocytes. Note also the dermal fibrosis. H&E. (D) Reduction in the initial fungal load showing the presence of black-stained round yeasts, some with narrow-base single buds, or cigar-shaped cells, and hyphae. GMS.