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. 2018 Jun 13;9:2320. doi: 10.1038/s41467-018-04411-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Complete peptide-to-protein network in the D. melanogaster vs. D. virilis species comparison. The network shows redundant peptides or proteins in single nodes. Peptide nodes are displayed as rectangles and protein nodes are ellipses (blue for D. melanogaster, green for D. virilis). Protein nodes comprising proteoforms of both species are shown in pink. Edges and peptide node outlines in red indicate that the relative quantification significantly deviates from the additional peptide nodes in a protein pair within a peptide-to-protein cluster. Relative abundance of peptide nodes is in the two-sample comparison is color-coded: peptide nodes in white, red, or blue are measured with a ratio, +∞ (+INF), or −∞ (−INF), respectively. The network is available online: Network 2,