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. 2018 May 30;2018:4528184. doi: 10.1155/2018/4528184

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Copyright © 2018 Woong Bi Jang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

MHY-1684 attenuates mitochondrial fission via regulating fission/fusion-related proteins. (a) Confocal image of hCPCs stained with MitoTracker Red CMXRos after cotreatment with 1 μM MHY-1684 and 25 mM D-(+) glucose for 72 h. (b) Mitochondrial length was analyzed when hCPCs were incubated with 1 μM MHY-1684 after being exposed to 25 mM D-(+) glucose. Results are presented as means ± SD. ^∗ p < 0.05 versus 25 mM D-(+) glucose. (c) Expression of the mitochondrial fragmentation-related marker Fis1, Drp1, OPA1, and Mfn1 when incubated with 1 μM MHY-1684 after being exposed to 25 mM D-(+) glucose.