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Plasma alpha-tocopherol concentration (μg/ml) delivered in PLGA, PLGA-Chi and in free form orally to F344 rats (n=6 per treatment). Three rats per treatment were bled at 0, 2, 8, 24, 48 and 72 hours while the remaining rats in each group were bled at 0, 4, 12, 36 and 72 hours. The concentrations were detected using positive ion mass spectroscopy.
