Cholestatic pattern of liver injury
	First Exposure	Second Exposure	Points
Time to onset of injury: a. from the beginning of the drug b. from cessation of the drug	5-90 days	1-15 days	2
	<5 or >90 days	>15 days	1
	≤ 30 days	≤ 30 days	1
Risk factors	Alcohol		1
	Age > 55		1
Course of the reaction	≥ 50% improvement within 180 days		2
	< 50% improvement within 180 days		1
	Persistence or increase or lack of information		0
Concomitant therapy	None		0
	Suggestive to onset of injury		-1
	Known hepatotoxin with suggestive time to onset of injury		-2
	Clear evidence for its role		-3
Other Causes	Ruled out		2
	Probable		-3
Previous Hepatotoxicity Info	Published and labelled		2
	Published not labelled		1
	Unknown		0
Response to reexposure	Not done		0

Likelihoods:  >8 Highly probable,  6-8 Probable, 3-5 Possible, 1-2 unlikely, 0 excluded